Genetic control of alphavirus pathogenesis
نویسندگان
چکیده
منابع مشابه
Molecular Mechanisms Involved in the Pathogenesis of Alphavirus-Induced Arthritis
Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), and Barmah Forest virus (BFV), cause incapacitating and long lasting articular disease/myalgia. Outbreaks of viral arthritis and the global distribution of these diseases point to the emergence of arthritogenic alphaviruses as an importa...
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Alphaviruses, a group of positive-sense RNA viruses, are globally distributed arboviruses capable of causing rash, arthritis, encephalitis, and death in humans. The viral replication machinery consists of four nonstructural proteins (nsP1-4) produced as a single polyprotein. Processing of the polyprotein occurs in a highly regulated manner, with cleavage at the P2/3 junction influencing RNA tem...
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ژورنال
عنوان ژورنال: Mammalian Genome
سال: 2018
ISSN: 0938-8990,1432-1777
DOI: 10.1007/s00335-018-9776-1